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Karen Aiach

Founder, Chief Executive Officer

Founder and CEO of Lysogene, Ms. Aiach is also the mother of a child with MPS IIIA. She has a strong business background starting her career with Arthur Andersen specializing in audit and transaction services. Her entrepreneurial experience includes founding and running a financial business consultancy. From 2008 to 2009, Ms. Aiach served as a Member of the Pediatric Committee at the European Medicines Agency (EMA), established in accordance with the European Pediatric Regulation, as a patient representative. In 2008, she also served on the French Ethical Review Board CCPPRB at Ambroise Paré Hospital.  Ms. Aiach has been involved with several not-for-profit organizations engaged in advocacy and research in the field of rare diseases such as Alliance Sanfilippo and Eurordis, where she served on the board as treasurer from 2010 to 2011. She is a founding executive member of the International Rare Diseases Research Consortium (IRDiRC).

Ms. Aiach graduated from the ESSEC Business School and majored in Economics.


Philippe Mendels-Flandre

Chief Operating Officer

Philippe Mendels - Flandre’s role is to support the CEO in all strategic initiatives and corporate governance matters, supervising Strategy, Legal, Communications, as well as Business Development.

Mr. Mendels-Flandre has 20 years of leadership experience in the field of biotechnology and finance. Before joining Lysogene, he was Emerging Markets General Manager at Shire. Prior to joining Shire, he held senior management roles in marketing, sales, finance and BD/strategy at Baxter/Baxalta. Throughout his career, Mr. Mendels-Flandre has developed a profound multidisciplinary expertise in international projects management; building expertise in disease areas including dialysis, nutrition and, most noticeably, rare diseases like hemophilia or lysosomal storage diseases.

Mr. Mendels-Flandre graduated with honors in Applied Economics from the Institut d’Administration et de Gestion, Université Catholique de Louvain-La-Neuve in Belgium. He is certified in Lean Management from Baxter and Strategic Marketing from HEC Executive, Paris.


Mark Plavsic

Chief Technical Officer

Mark is responsible for Lysogene’ s manufacturing strategy and CMC operational development. He has extensive technical experience across a diverse range of functions, proven knowledge of quality compliance and regulatory requirements and strong business and leadership skills gained from over 30 years of experience working in North America, Europe and Australasia.  Prior to joining Lysogene, Mark worked as Head of Process Development and Manufacturing at Torque Therapeutics, leading multiple functions including process and analytics development and ensuring quality controls and design across manufacturing.  Prior to that, Dr. Plavsic held multiple positions with Sanofi Genzyme, Astra Zeneca and Invitrogen Corporation.

Dr. Plavsic received his Ph.D in Virology and Molecular Cell Biology, M.S. in Virology and Immunology, and Doctor of Veterinary Medicine degree from the University of Belgrade in Yugoslavia.  He has a Board certification in Microbiology, subspecialty Virology from the American College of Veterinary Microbiologists.


Sophie Olivier

Chief Medical Officer

Sophie Olivier is responsible for clinical development.  A physician by background, Sophie Olivier has extensive clinical development experience in large and small pharma organizations and has overseen multiple regulatory interactions with both the FDA and the EMA, particularly in regard to pediatric regulation. Prior to joining Lysogene, Sophie Olivier was Chief Medical Officer at Genticel.  Before joining Genticel, Sophie Olivier worked as Scientific Officer, Pediatric Team, at the European Medicines Agency in London.  Previously, Sophie Olivier led clinical development in Women’s Health diseases at Wyeth Pharmaceutical (Philadelphia Area, US). With her extensive career as a senior manager in the industry, spanning from early development to ensuring market access, Sophie Olivier brings a rich breadth of experience across a variety of therapeutic areas to Lysogene.


Samantha Parker

Samantha Parker

Chief Patient Access Officer

Samantha Parker is Head of Lysogene’s Patient and Policy Affairs. Ms. Parker has specialised in rare disease research and public health since 2000. She has focused on expanding the expert disease community of healthcare professionals, patients, industry and regulators; building disease registries and natural history studies; developing consensus care guidelines; and developing strategies to improve the quality of diagnosis and patient care. Ms. Parker contributed, for several years, to the area of independent professional education in rare diseases. She is a member of the European Group of Experts on Rare Diseases (EGRD) and the International Rare Diseases Research Consortium (IRDiRC).

Ms. Parker has a B.A. (Hons) from Edinburgh University and an M.B.A (with distinction) in Life Sciences.


Sean O’Bryan

Vice President of Regulatory Affairs and Quality Assurance

Sean is responsible for providing global regulatory strategic leadership and for the creation and maintenance of quality systems assuring global compliance.  Prior to joining Lysogene, he was the Director of Regulatory Affairs at bluebird bio leading efforts on the treatment of the rare disease CCALD through LVV gene therapy where he initiated and led the RA CMC group across all programs including CNS, hematology and oncology.  Prior to this, he worked 8 years at Genzyme/Sanofi serving as a global regulatory lead for the Cell Therapy and Regenerative Medicine division.  Sean has more than 20 years of regulatory experience across a range of categories including biologics, gene therapy, chemistry, manufacturing and control (CMC) and medical device

Sean holds a BS in Biology and Analysis and Policy from Boston University and is RAPs certified.


Sarah Ankri

Vice President Finance

Sarah is responsible for overseeing Lysogene’s financial operations, budget and financing strategy.  Prior to joining Lysogene, she was Chief Financial Officer at Theraclion where she successfully led the company’s IPO in 2014.  She acquired her financial knowledge related to Bio- and Medtech companies, including fundraising (Europe and USA) during the six years she spent at Ernst & Young working on legal audit and advisory/acquisition missions in the healthcare sector. She has more than 10 years of experience in financial operations accross Life Sciences industry.

Sarah is a graduate of the National Institute of Agronomy (INA P-G/AgroParisTech) and has a Masters in Economy and Management.

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